Research use only ✓ COA DSIP Spray

Neuropeptides, Sprays

DSIP Spray Delta sleep-inducing peptide

Name: DSIP Spray
Brand: Clean Peptide
SKU: dsip-spray
Price: 87.49 USD
Availability: InStock

CAS 62568-57-4 BATCH 202609DSSP20

DSIP (delta sleep-inducing peptide, emideltide) is the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from rabbit blood in 1977. This DSIP nasal spray holds 20 mg in a 20 mL bottle, already in solution, with a lot certificate.

Mass

Clear

Quantity

−30% applied

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Verified test results

Every batch, independently verified.

Each batch is analyzed by an independent third-party laboratory before it ships. This is the released report for the size selected above, exactly as the lab issued it.

HYTE Research DivisionIndependent third-party laboratory

Lot: 202609DSSP20
Tested: Sep 17, 2026
Labeled: 20mL
Measured: 1.18mg/mL

2× tested

Full QC panel

2 passed

Identity

HPLC-DAD

DSIP confirmedPass

Quantity

Curve Assay · spec NLT 90% of label claim

1.18mg/mLPass

What is DSIP?

Delta sleep-inducing peptide was isolated in Basel by Schoenenberger, Monnier and colleagues from the cerebral venous blood of rabbits whose thalamus was being electrically stimulated to induce sleep. Infused into the brains of other rabbits, the peptide increased slow-wave (delta) EEG activity, which gave it its name. Its sequence, WAGGDASGE, was reported in 1977 and synthesised in 1978.

Almost fifty years on, DSIP is still something of a puzzle. No gene, precursor protein or receptor for it has been isolated, and a 2006 review in the Journal of Neurochemistry called it “a still unresolved riddle”. Its structure does not resemble any other known peptide family.

DSIP identity

Names	DSIP, delta sleep-inducing peptide, emideltide (INN)
Sequence	`WAGGDASGE` (H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH)
Structure	Linear nonapeptide, all L-amino acids, free termini
Molecular formula	C₃₅H₄₈N₁₀O₁₅
Molecular weight	848.8 g/mol
CAS number	62568-57-4
PubChem CID	68816
Receptor	None identified
This product	20 mg DSIP in 20 mL solution, spray bottle

PubChem also lists CAS 69431-45-4 for a second registry record. Source: PubChem CID 68816.

Certificate for the current lot

Each bottle is filled from one lot and ships against that lot’s certificate. The current DSIP spray lot was tested for identity and quantity by HPLC:

Size	Lot	Laboratory	Analysed	Measured content	Identity
20mL	202609DSSP20	HYTE Research Division	17 Sep 2026	1.18mg/mL	DSIP confirmed

Transcribed from the certificate issued for each size on sale today. Open the signed certificate for any size under Verified test results above. Every DSIP Spray COA, lot by lot

The certificate reports identity and concentration only; it does not report an HPLC purity figure.

Published research on DSIP

Discovery (rabbits, 1977). The isolated peptide enhanced delta and spindle EEG activity under double-blind conditions; of nine synthetic peptides tested, only synthetic DSIP did so. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Schoenenberger GA, Monnier M. PNAS, 1977.
Sequence and synthesis (1978). Synthetic DSIP raised delta activity by a mean of 35% in neocortex and limbic cortex; only the alpha-aspartyl form was highly active, not its beta-Asp isomer. The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide. Schoenenberger GA, et al. Pflügers Archiv, 1978.
Crossing the blood-brain barrier (rabbits, 1977). Given intravenously, synthetic DSIP increased cortical delta activity and reduced motor activity over five hours. Transport of the synthetic peptide DSIP through the blood-brain barrier in rabbit. Monnier M, et al. Experientia, 1977.
Review of the first decade (1984). DSIP-like material was detected in brain, peripheral organs and plasma, with reported effects on EEG, neurotransmitters, circadian patterns and hormone levels and a U-shaped dose-response. Delta-sleep-inducing peptide (DSIP): a review. Graf MV, Kastin AJ. Neuroscience and Biobehavioral Reviews, 1984.
The human studies disagree. Small intravenous studies in the 1980s reported sleep effects in people with insomnia; a 1992 double-blind study in 16 patients found only weak effects and concluded short-term DSIP was unlikely to be of major benefit. Schneider-Helmert D, et al. Neuropsychobiology, 1983; Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Bes F, et al. Neuropsychobiology, 1992.
Where the field stands (2006). The link between DSIP and sleep was never characterised further, partly because no DSIP gene, protein or receptor has been found; the authors propose that an unidentified DSIP-like peptide underlies the activity. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Kovalzon VM, Strekalova TV. Journal of Neurochemistry, 2006.

The published DSIP studies used infusion into the brain or intravenous injection. We did not find a published study of nasal administration.

Regulatory status

DSIP is not an approved drug in the US. FDA’s compounding safety-risk page lists “Emideltide (DSIP)” among nominated-but-withdrawn substances. A 2022 review lists a Russian preparation with the DSIP sequence, Deltaran, among peptide products registered there. FDA compounding safety-risk list; Deigin VI, et al. Pharmaceutics, 2022. Clean Peptide’s DSIP spray is for laboratory research only.

Related research

Other ready-made sprays: Selank Spray, Semax Spray, PT-141 Spray and Adamax Spray.
Epithalon: another short synthetic peptide in the catalogue, with its own certificate.
All research sprays.
How to read a peptide certificate of analysis.

Technical specification

What is on file, and how it is handled

Every figure below is transcribed from the paperwork for this compound.

Material

Compound: DSIP Spray (Delta sleep-inducing peptide)
Class: Neuropeptide (nonapeptide)
Form: Solution: 20 mg in 20 mL, spray bottle
Sizes: 20mL
Sequence: WAGGDASGE (H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH)
Formula: C35H48N10O15
CAS: 62568-57-4
Mol. weight: 848.8 g/mol
Residues: 9

Verification

Identity: Confirmed on the certificate of analysis
Purity: See certificate
Batch: 202609DSSP20
Documentation: Per-batch certificate of analysis

Handling

Storage: Store at −20 °C, protected from light
Intended use: In-vitro laboratory research only

Compound data on PubChem

QuestionsDSIP Spray: frequently asked

What is DSIP?+

DSIP, delta sleep-inducing peptide (emideltide), is the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, isolated from rabbit blood by Schoenenberger and Monnier in 1977.

What is in the DSIP nasal spray bottle?+

20 mg of DSIP in 20 mL of solution. The current lot’s certificate confirms identity by HPLC-DAD and reports the measured concentration.

Does DSIP have a known receptor?+

No. No DSIP gene, precursor protein or receptor has been isolated, which is why a 2006 review called it an unresolved riddle.

What is the DSIP molecular weight?+

848.8 g/mol (C35H48N10O15, PubChem CID 68816). PubChem lists CAS 62568-57-4.

Was DSIP studied as a nasal spray?+

Not that we could find. The published studies gave DSIP by infusion into the brain or by intravenous injection.

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