Research use only ✓ COA Adamax Spray

Neuropeptides, Sprays

Adamax Spray

Name: Adamax Spray
Brand: Clean Peptide
SKU: adamax-spray
Price: 76.99 USD
Availability: InStock

BATCH 202609ADXSP20

Adamax is a research peptide sold as a Semax analogue, usually described as N-acetyl Semax with an adamantane group added. This Adamax nasal spray holds 20 mg in a 20 mL bottle, and its lot certificate confirms identity and measures the concentration. Unlike Semax, Adamax has no published research and no official structure record, as set out below.

Mass

Clear

Quantity

−30% applied

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Verified test results

Every batch, independently verified.

Each batch is analyzed by an independent third-party laboratory before it ships. This is the released report for the size selected above, exactly as the lab issued it.

HYTE Research DivisionIndependent third-party laboratory

Lot: 202609ADXSP20
Tested: Sep 17, 2026
Labeled: 20mL
Measured: 0.98mg/mL

2× tested

Full QC panel

2 passed

Identity

HPLC-DAD

Adamax confirmedPass

Quantity

Curve Assay · spec NLT 90% of label claim

0.98mg/mLPass

What is Adamax?

Adamax is a name used by research-peptide sellers, not an official one: it has no INN, no CAS number, no FDA substance record (UNII) and no PubChem compound entry. It is marketed as a modified form of Semax, the Russian heptapeptide MEHFPGP.

The most repeated description, from the Wikipedia article on Adamax (created October 2025), is Semax with an acetyl group on the N-terminus and the C-terminal proline linked to a 3-carbamoyl-1-adamantyl group. That would be C₅₀H₆₉N₁₁O₁₁S, about 1,032 g/mol. The adamantane unit is borrowed from P021, a different, published research peptide from the Iqbal laboratory in New York. Other vendor listings give different sequences and formulas, one of them with no adamantane at all. None of these structures comes from a characterisation study, so we do not state any of them as fact.

What is known and what is not

Names	Adamax; also listed as N-acetyl Semax adamantane, Ac-MEHFPGP-adamantyl-NH₂
Described as	A Semax (ACTH(4-7)-Pro-Gly-Pro) analogue with N-terminal acetylation and a C-terminal adamantyl amide
Most-cited formula	C₅₀H₆₉N₁₁O₁₁S, about 1,032 g/mol (Wikipedia and two vendors; not confirmed by any primary source)
CAS, UNII, PubChem CID	None assigned
Peer-reviewed research	None found (PubMed, PMC, Europe PMC and patent searches, October 2026)
Clinical trials	None registered
Parent peptide	Semax, MEHFPGP, C₃₇H₅₁N₉O₁₀S, 813.9 g/mol, CAS 80714-61-0
This product	Solution, 20 mg Adamax in 20 mL (nominal 1 mg/mL), spray bottle

Certificate for the current lot

Every bottle is filled from one lot and ships against that lot’s certificate, issued by HYTE Research Division. Identity is reported as confirmed by HPLC with diode-array detection (the certificate does not give the reference structure), and the concentration is measured against a specification of not less than 90% of the label claim:

Size	Lot	Laboratory	Analysed	Measured content	Identity
20mL	202609ADXSP20	HYTE Research Division	17 Sep 2026	0.98mg/mL	Adamax confirmed

Transcribed from the certificate issued for each size on sale today. Open the signed certificate for any size under Verified test results above. Every Adamax Spray COA, lot by lot

The spray certificate reports identity and concentration; it does not report an HPLC purity figure.

The research that does exist

Because Adamax itself is unstudied, the papers below are about its two ingredients, Semax and the adamantane unit. They describe those molecules, not Adamax, and their findings cannot be carried over to it.

Semax and BDNF (rats, 2006). Semax bound specific sites in rat basal-forebrain membranes, and intranasal Semax raised BDNF protein there within three hours. Dolotov OV, et al. Journal of Neurochemistry, 2006. More on the Semax page.
The adamantane peptide P021 (mice, 2010). The founding paper on Ac-DGGL(A)G-NH₂, a peptide derived from ciliary neurotrophic factor with an adamantylated glycine at its C-terminus, studied in adult mice. Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice. Li B, et al. FEBS Letters, 2010.
Why add adamantane (2017). P021’s developers state that the adamantylated glycine was added to raise blood-brain barrier permeability and reduce breakdown by exopeptidases. Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound. Baazaoui N, Iqbal K. Alzheimer’s Research & Therapy, 2017.
Adamantane in drug design (2013). A review of adamantane-containing drugs, which notes that adding adamantane to neuropeptides often changes receptor selectivity and stability. The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives. Wanka L, et al. Chemical Reviews, 2013.

Regulatory status

Adamax is not an approved drug anywhere and has no FDA application. It does not appear on FDA’s 503A or 503B compounding category lists or its compounding safety-risk page, where Semax does. In New Zealand, Medsafe’s June 2025 submission to the Medicines Classification Committee named Adamax and Semax as ACTH analogues marketed as cognitive enhancers and proposed classifying the group as prescription medicines; the committee deferred its decision in July 2025. Medsafe submission, June 2025. Clean Peptide’s Adamax Spray is for laboratory research only, not for human or veterinary use.

Related research

Semax Spray and the Semax 10 mg vial, the peptide Adamax is based on.
Selank Spray and Selank vs Semax.
All peptide nasal sprays.

Technical specification

What is on file, and how it is handled

Every figure below is transcribed from the paperwork for this compound.

Material

Compound: Adamax Spray
Class: Semax analogue (research peptide; structure not published)
Form: Solution: 20 mg in 20 mL, spray bottle
Sizes: 20mL

Verification

Identity: Confirmed on the certificate of analysis
Purity: See certificate
Batch: 202609ADXSP20
Documentation: Per-batch certificate of analysis

Handling

Storage: Store at −20 °C, protected from light
Intended use: In-vitro laboratory research only

QuestionsAdamax Spray: frequently asked

What is Adamax?+

Adamax is a research peptide sold as a Semax analogue, most often described as N-acetyl Semax with a C-terminal adamantyl group. It has no INN, CAS number, FDA substance record or PubChem compound entry, and no published study defines its structure.

What is the Adamax peptide formula?+

The most-cited formula, from Wikipedia and two vendors, is C50H69N11O11S, about 1,032 g/mol. Other vendors list different formulas, and no primary source confirms any of them, so we do not state one as fact.

Is there research on Adamax?+

No peer-reviewed study of Adamax was found in PubMed, PMC, Europe PMC or patent databases as of October 2026, and no clinical trial is registered. The published research is on Semax and on P021, the adamantane peptide its design borrows from.

What is the difference between Adamax and Semax?+

Semax is a defined, published heptapeptide, MEHFPGP (C37H51N9O10S, CAS 80714-61-0). Adamax is described as Semax with an added acetyl group and an adamantane unit, but that structure has not been published.

What is in the Adamax nasal spray?+

20 mg of Adamax in 20 mL, a nominal 1 mg per mL, in a spray bottle. The current lot’s HYTE Research Division certificate reports identity as confirmed by HPLC-DAD and gives the measured concentration.

Is Adamax FDA-approved?+

No. It has no FDA application and is not on FDA’s compounding lists. New Zealand’s Medsafe named it in 2025 among ACTH analogues it proposed to classify as prescription medicines.

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