Selank TP-7
Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP): the immunopeptide tuftsin with a Pro-Gly-Pro tail for stability. This Selank peptide is a 10 mg lyophilised vial with a per-lot ILS Laboratories certificate.
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Verified test results
Every batch, independently verified.
Each batch is analyzed by an ISO/IEC 17025 accredited third-party laboratory before it ships. This is the released report for the size selected above, exactly as the lab signed it.
Certificate of analysis
99.90%
Purity by HPLC
- Lot
- ACE-2779576
- Tested
- Sep 3, 2026
- Labeled
- 10mg
- Measured
- 10.4mg
Full QC panel
5 passed · 2 reportedPurity
HPLC
Net Peptide Content
Identity
HPLC
Fentanyl Screen
Heavy Metals
ICP-MS
Sterility
PCR
Endotoxin
USP <85>
What is Selank?
Selank was designed at the Institute of Molecular Genetics of the Russian Academy of Sciences, with the V.V. Zakusov Research Institute of Pharmacology. Its first four residues, Thr-Lys-Pro-Arg, are tuftsin, a short fragment of the immunoglobulin G heavy chain. The C-terminal Pro-Gly-Pro (a “glyproline”) was added to slow enzymatic breakdown and prolong its action.
The same stabilising tail is used in Semax, which pairs it with a fragment of ACTH instead of tuftsin. For a side-by-side view of the two, see Selank vs Semax.
Selank identity
| Names | Selank, TP-7, Selanc |
|---|---|
| Sequence | TKPRPGP (H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH) |
| Structure | Linear heptapeptide, all L-amino acids, free termini |
| Molecular formula | C33H57N11O9 (free peptide) |
| Molecular weight | 751.9 g/mol (free peptide) |
| CAS number | 129954-34-3 |
| PubChem CID | 11765600 |
| Parent peptide | Tuftsin (Thr-Lys-Pro-Arg) |
| This product | 10 mg, lyophilised powder |
Research material is often supplied as a salt (for example the acetate), so its formula weight can differ from the free peptide’s. Source: PubChem CID 11765600.
Certificate for the current lot
The current Selank lot was analysed by ILS Laboratories in San Diego, which states ISO/IEC 17025 accreditation for activities within its published scope:
| Size | Lot | Laboratory | Analysed | HPLC purity | Measured content | Identity |
|---|---|---|---|---|---|---|
| 10mg | ILS Laboratories | 3 Sep 2026 | 99.90% | 10.4mg | Selank |
Transcribed from the certificate issued for each size on sale today. Open the signed certificate for any size under Verified test results above. Every Selank COA, lot by lot
How Selank has been studied
No single receptor for Selank has been identified. The mechanisms proposed in the literature are:
- Enkephalin-degrading enzymes. In human plasma, Selank inhibited the enzymatic breakdown of enkephalins (IC50 15 µM), more potently than bacitracin or puromycin. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Zozulya AA, et al. Bulletin of Experimental Biology and Medicine, 2001.
- GABAergic gene expression (rats). A single intranasal dose changed the expression of dozens of GABAergic neurotransmission genes in the frontal cortex, and the changes at one hour correlated with those produced by GABA. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Volkova A, et al. Frontiers in Pharmacology, 2016.
- BDNF in the hippocampus (rats). A 2008 paper reports that intranasal Selank regulated BDNF expression in the rat hippocampus. In a 2019 study of rats given ethanol for 30 weeks, Selank prevented the ethanol-induced rise in hippocampal and frontal-cortex BDNF and the memory disturbances seen on withdrawal. Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. Inozemtseva LS, et al. Doklady Biological Sciences, 2008; Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Kolik LG, et al. Bulletin of Experimental Biology and Medicine, 2019.
Clinical work on Selank comes almost entirely from Russia and is mostly published in Russian. Two comparative studies, in 62 and 60 patients, compared it with the benzodiazepines medazepam and phenazepam using standard anxiety rating scales. Zozulia AA, et al., 2008; Medvedev VE, et al., 2014. Zhurnal Nevrologii i Psikhiatrii. ClinicalTrials.gov lists no Selank studies.
Regulatory status
A 2022 review lists Selank among the peptide products registered in the Russian Federation. In the US it is not an approved drug, and FDA’s page on bulk substances that may present significant safety risks in compounding lists “Selank acetate (TP-7)” among nominated-but-withdrawn substances, noting limited human safety information. Development of Peptide Biopharmaceuticals in Russia. Deigin VI, et al. Pharmaceutics, 2022; FDA compounding safety-risk list. Clean Peptide’s Selank is a laboratory reference material only.
Related research
- Selank Spray: the same peptide, 20 mg in a 20 mL spray bottle, already in solution.
- Semax and Semax Spray: the ACTH(4-7) glyproline.
- Selank vs Semax: structure, research and evidence side by side.
- All neuropeptides.
What is on file, and how it is handled
Every figure below is transcribed from the paperwork for this compound.
Material
- Compound
- Selank
- Class
- Tuftsin analogue (glyproline heptapeptide)
- Form
- Lyophilised powder
- Sizes
- 10mg
- Sequence
- TKPRPGP (H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH)
- Formula
- C33H57N11O9
- CAS
- 129954-34-3
- Mol. weight
- 751.9 g/mol
- Residues
- 7
Verification
- Identity
- Confirmed on the certificate of analysis
- Purity
- ≥ 99.9% by HPLCSee certificate
- Batch
- ACE-2779576See certificate
- Documentation
- Per-batch certificate of analysis
Handling
- Storage
- Store at −20 °C, protected from light
- Intended use
- In-vitro laboratory research only
QuestionsSelank: frequently asked
What is Selank?+
Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is tuftsin (Thr-Lys-Pro-Arg) extended by a Pro-Gly-Pro tail, developed at the Institute of Molecular Genetics, Russian Academy of Sciences.
What is the Selank peptide sequence?+
TKPRPGP, or H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH. The formula of the free peptide is C33H57N11O9 (751.9 g/mol), CAS 129954-34-3.
What is the difference between Selank and Semax?+
Both end in the same Pro-Gly-Pro stabilising unit. Selank starts with tuftsin (Thr-Lys-Pro-Arg); Semax starts with the ACTH(4-7) fragment (Met-Glu-His-Phe).
What is the difference between Selank and Selank Spray?+
Same peptide, different form. This product is 10 mg of lyophilised powder in a vial; Selank Spray is 20 mg already in a 20 mL solution.
Is Selank FDA-approved?+
No. It is reported as registered in Russia. FDA lists Selank acetate among bulk substances nominated, then withdrawn, from its compounding safety-risk category.
What does the Selank certificate show?+
The current 10 mg lot, ACE-2779576, was analysed by ILS Laboratories on 3 September 2026: 99.90% HPLC purity, 10.4 mg net peptide content and identity confirmed as Selank.
